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Charles Toth, chair.

Developmental Biology

Associate Professor

 

 

Education:

 

Ph.D., University of Virginia, 1993

B.S. University of Toledo, 1987

 

 

Contact Information

 

email: ctoth@providence.edu

Phone: 401-865-2015 (office) x 1632 (lab)

Office: Sowa 236A

 

 

Courses taught:

 

BIO200 Cell Biology and Molecular Genetics

BIO320 Developmental Biology

BIO416 Immunology

 

 

Research

 

All blood cells are created by the pathway of hematopoiesis, which is the differentiation of pluripotent stem cells into fully formed mature blood cells. In adults, hematopoiesis occurs in the bone marrow by the directed differentiation of these stem cells. The genes and proteins associated with blood cell differentiation are an important topic of research. Previous research has determined a gene locus, c-myb, which is involved in hematopoietic differentiation. This gene is predominately expressed in progenitor cells of adult bone marrow and is regulated by the transcription factor family NF-kB. My project is to study hematopoiesis using human induced pluripotent stem cells (iPSC). From these stem cells, formation of embryoid bodies and treatment with specific growth factors will produce hematopoietic stem cells that can be studied for changes in gene expression.

 

 

Recent Publications:

 

Toth, C. and Connelly, R.  A Bioinformatics experience course. 2006. Journal of Computing Sciences in Colleges. 21(6): 100-107.

Ingham, R. R., Gesualdi, D. A., Toth, C. R., Clotfelter, E. D. Effects of Genistein on Growth and Development of Aquatic Vertebrates. 2004. Bull. Environ. Contam. Toxicol. 72:625-631.

Zavada, M.S., DiMichele, L., and C. Toth. The demi-lichenization of Tremetes veriscolor II. The transfer of fixed 14CO2 from the algal epiphyte to the fungus. 2004. Northeast Naturalist. 11(1): 33-40.

Toth, C.R. and Coffino, P.  Regulated degradation of yeast ornithine decarboxylase.  1999.  Journal of Biological Chemistry.  274:25921-25926.

Toth C.R., Hostutler, R.F., Baldwin, A.S. Jr., Bender T.P.  1995.  Members of the NF-kB family transactivate the murine c-myb geneJournal of Biological Chemistry.  270(13):7661-7671.

 
 
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