Courses Recently Taught:
Biology 103: General Biology (download
syllabus)
Biology 104: General Biology
Biology 405: Human Physiology (download
syllabus)
Biology 475: Signal Transduction (download
syllabus)
Biology 450: Internship
Biology 497: Research
Courses to be taught or under consideration:
Biology 122: Human Biology
Biology 398: Research
Biology 498: Research
Bioinformatics
Research Interests
My research interests are in cell signaling from receptor
activation to transcription factor regulation. Effects of
environmental factors such as UV and arsenite on apoptosis or unwanted
growth/development are under cellular and molecular investigation by using
cultured cell lines or plant systems. Undergraduate research opportunities
exist in my laboratory.
Education
1996 -1999 The University of Michigan (Postdoctoral
Fellowship)
1992 -1996 University of Louisiana at Lafayette (Ph.D.)
1984 -1987 Nanjing University of Agriculture (M.S.)
1980 -1984 Nanjing University of Agriculture (B.A.)
Recent Publications
Wan YS, Wang ZQ, Shao Y, Fisher GJ, Voorhees JJ (2001) Transmodulation
of epidermal growth factor receptor mediates IL-1-induced MMP-1 expression
in cultured human keratinocytes. Int J Molecular Medicine. 7, 329
Wan YS, Wang ZQ, Shao Y, Fisher GJ, Voorhees JJ (2001) UVB activates
PI-3 kinase/PKB pathway in cultured keratinocytes in vitro and human skin
in vivo. Int J Oncology, 18, 461
Wan YS, Wang ZQ, Voorhees JJ, Fisher GJ (2001) EGFR mediates cross-talk
among cell surface receptors leading to the activation of c-Jun kinase in
human keratinocytes upon UV irradiation. Cell Signal. 13, 139
Xu YR, Wan YS, Voorhees JJ, and Fisher GJ (2000) Activation of
epidermal growth factor receptor by ultraviolet irradiation occurs via
inhibition of membrane protein tyrosine phosphatases by reactive oxygen
species. J Invest Derm. 114, 794
Wan YS, Wang ZQ, Shao Y, Xu YR, Duell EA, Fisher GJ, Voorhees JJ (2000)
UV-induced expression of GADD45 is mediated by an oxidant sensitive
pathway in cultured human keratinocytes and human skin in vivo. Int J
Molecular Medicine. 6, 683
Wang ZQ, Wan YS, Fisher GJ, Voorhees JJ (1999) UV
activates NF-kB through an antioxidant-sensitive pathway that is
independent of cytokines in human keratinocytes and skin in vivo. J
Invest. Derm. 112, 561
Kang SW, Fisher G, Duell EA, Wan YS, Varani J,
Voorhees JJ (1999) The antioxidants N-acetyl cysteine increases the
content of the endogenous antioxidant glutathione and prevents
UV-induction of matrix metalloproteinases in human skin in vivo. J
Invest. Derm. 112, 658
Fisher GJ, Talwar HS, Lin JY, Lin PP, McPhillips F, Wang
ZQ, Li XY, Wan YS, Kang SW, Voorhees JJ (1998) Retinoic acid
inhibits ultraviolet irradiation induction of c-Jun protein that occurs
subsequent to activation of MAP kinase pathways in human skin in vivo.
J Clinical Investigation. 101, 1432
Wan YS, Fisher GJ, Voorhees JJ (1998) Ultraviolet
irradiation generates reactive oxygen through activation of cell surface
receptor-coupled NADPH oxidase in human keratinocytes and human skin in
vivo. J Invest. Derm. 110, 489
Lin JY, Wan YS, Bata-Csorgo Z, Talwar HS, Kang SW,
Fisher GJ, Voorhees JJ (1998) Ultraviolet irradiation rapidly activates
cell surface receptors and three distinct MAP kinase modules in human skin
in vivo. J Invest. Derm. 110, 474
Wan YS, Hasenstein KH (1996) Purification of ABA
binding protein and antibody preparation. J. Molecular Recognition. 4, 120
Wan YS, Hasenstein KH (1996) Affinity
chromatography for the purification of anti-ABA IgG and anti-idiotypic
antibody. Int. J. Biochromatography. 2, 77
Sang YM, Zhou X, Zhang NG, Wan YS, He ZY (1994)
Localization of abscissic acid binding proteins in maize root tips using
immunogold-silver staining method. Science in China (series B). 37, 1146
Wan YS, Hasenstein KH (1995) Purification of ABA
binding proteins by affinity chromatography. Plant Physiol. 108, 80
Wan YS, Hasenstein KH (1993) Immunological
investigation of ABA receptors in corn roots. Plant Physiol. 102, 62
Wan YS, Hasenstein KH (1994) Characterization of
anti-idiotypic antibodies. Plant Physiol. 105, 96
Wan YS, Tang JD, Zhang NG, Zhou X, Du NX (1992)
Production and identification of anti-idiotypic antibodies of ABA. Plant
Physiology Communications. 3, 212
Wan YS, Tang JD, Zhang NG, Zhou X, Du NX (1991)
Purification of ABA binding proteins from corn roots by affinity
chromatography. Plant Physiology Communications. 5, 38
Wan YS, Wu SR, Li SJ, Zhou X (1989) Effects of
PP333 on plant model of pepper in soilless seedlings, Plant Physiology
Communications. 1, 52
