Position
Academic Background  
Sample Courses
Teaching Philosophy
Research & Interests   
Notable Academic Appointments & Awards
Publication Highlights  
Selected Scholarly Presentations

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Position            

• Associate Professor of Biology

Academic Background         

• The University of Michigan – Postdoctoral Fellowship, 1996 -1999
• University of Louisiana at Lafayette – Ph.D., 1996
• Nanjing Agricultural University – M.S., 1987
• Nanjing Agricultural University – B.A., 1984

Sample Courses Taught at Providence College  

• General Biology
• Physiology
• Human Biology
• Cell Signaling

Teaching Philosophy            

Teaching is the profession I have actively pursued for years with all my heart. In my opinion, being an effective teacher means to have mastered subject matter, and to add to information values such that the learned knowledge is paired with wisdom. 
It is well accepted that hands-on research is a necessity for the students at the college level, and laboratory practice is often an untapped and eagerly awaited attraction for biology students. Therefore, my belief remains that it would be always beneficial to involve students in laboratory-based research.

Research & Interests               

Dr. Wan has conducted breakthrough dermatological research on the effects of ultraviolet radiation on skin aging and skin cancer. He has also collaborated with others to research immunotherapy as a way to enhance an individual’s ability to fight cancer. His interests include cell signaling from receptor activation to transcription factor regulation. Using cultured cell lines, he conducts cellular and molecular investigations on the effects of environmental factors such as UV and arsenite on apoptosis or unwanted growth/development. Undergraduate research opportunities exist in his laboratory.

Notable Academic Appointments and Awards

• Guest Professor, Dermatology Dept. Nanjing Medical University, Nanjing, China
• 1^st Place Prize, Annual Mount Sinai Medical School Winter Symposium, Dec. 10, 2003, New York
• ASMBM Undergraduate Faculty Travel Award 2001
• ASMBM Undergraduate Faculty Travel Award 2000

Publication Highlights

• P Zhang, J Chen, AM Dragoi, X Gong, S Ivanov, ZW Li, T Chuang, C Tuthill, YS Wan, M Karin, WM Chu (2005) Activation of IKK by thymosin alpha 1 demands the TRAF6 signaling pathway. EMBO Report. In Press.
• Q Wang, A Turlington, S Heo, A Blanco, J Tian, Z Xie, BF Yan, YS Wan (2005) Extracellular matrix activity and caveolae events contribute to cell surface receptor activation that leads to MAP kinase activation in response to UV irradiation in cultured human keratinocytes. Int J Mol Med. in press.
• K Hokeness, LH Qiu, M Vezeridis, BF Yan, S  Mehta, YS Wan (2005) Paclitaxel-induced apoptosis in cultured human keratinocytes is enhanced by IFN-g and is modulated by activation of caspase 8 and 3 with a concomitant down regulation of the AKT survival pathway. Oncology Report, in press
• JM Luo, YS Wan, ZQ Liu, GR Wang, J Floros, HH Zhou (2004) Regularity of Distribution of Immunoreactive Pulmonary Surfactant  Protein A in Rat Tissues. Int J Mol Med., 14, 343-351         
• S Kang, JH Chung, JH Lee, GJ Fisher, YS Wan, EA Duell, JJ Voorhees. Topical N-acetyl cysteine and genistein prevent ultraviolet-light-induced signaling that leads to photoaging in human skin in vivo. J Invest Derm. 2003, 120, 835-841
• YX Li, MX Xie, XL Song, S Gragen, K Sachdeva, YS Wan, BF Yan. DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter. J Biol Chem. 278, 16899-16907
• JQ Yin, JS Cao, RG Shao, WN Tian, JP Wang, YS Wan. SiRNA agents inhibit oncogene expression and attenuate human tumor cell growth. J Exp Ther Onc. 2003, 3, 1-11
• QS Zhang GR Bratton, RK Agarwal, D Calise, G Kugel, YS Wan, AM Kumar. Lead-induced cell signaling cascades in GT1-7 cells. Brian Research Bulletin. 2003, 61: 207-17.
• JQ Yin and YS Wan. RNA-mediated gene regulation system: Now and the future. Int Mol Med. 2002, 10, 355-365

Selected Scholarly Presentations and Activities

• In December. 2004, invited and presented in University of Rhode Island, "Hypoxia and UV-induced Skin Cancer."
• In December. 2003, invited by and presented in Mount Sinai School of Medicine Annual Dermatology Symposium, "Molecular Mechanisms of UV-induced Skin Cancer."
• In October. 2003, invited by and presented in Korean Society of Dermatology and Seoul National University, Seoul, Korea, "Molecular Mechanisms of UV-induced Skin Aging and Skin Cancer."
• In July, 2003, invited by and presented in Nanjing Normal University College of Biological Sciences, "Molecular Mechanisms of UV-induced Skin Aging and Skin Cancer."
• In March, 2003, invited by and presented in Avon Products, New York, "Molecular Mechanisms of UV-induced Skin Aging."
• In November, 2002, invited by and presented in the International Conference on Modernization of Chinese Medicine. Chendu, China, "Utilization of Chinese Herb Extracts to Attenuate UV-induced Signaling that Leads to Skin Cell Damage."
  

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